Case Report #1

Patient Sh., female, born 1917. On November 3rd, 1975 she was operated on at the surgical department of the First Tuberculosis Hospital of the city of Moscow by Cand. med. sci. A.V. Doubrovskii for a mediastinal malignant tumour with metastases into the both lungs. The x-ray examination revealed in the right side of the chest an 8´13-cm massive intensive shadow adjacent to the shadow of the mediastinum and diaphragm. On the outside of this formation there are three round shadows up to 2 cm in size, located in the lower and middle lobes of the lung. In the left lung, there are two round shadows in the middle and lower pulmonary lobes, with a diameter of up to 1.5-2 cm.

Because of the life-threatening clinical picture of the compressed vena cava superior, the patient was subjected to right-sided thoracotomy, revealing a gigantic tumour originating from the middle lobe, intimally connected with the vena cava and grown into the pericardium. Subpleurally there were determined large dense formations with a diameter of up to 2 cm. The tumour was removed, as well as a part of palpated dense neoplasms. Histological study revealed the picture of squamous-cell carcinoma with elements of necrosis. In the postoperative period, the round foci seen prior to the operation remained in the left lung.

The IET (Immuno Embryo Therapy) commenced on November 25th, 1975 after immunologically revealing in the blood serum of the patient the blocking factors in high concentration. Following a single injection of placental preparations, patient Sh. showed in a month decreased metastatic shadow on the left, and in three months the roentgenological signs of metastases ceased to be revealed. 5 year after the operation and immunoembryotherapy the case was described (V.I. Govallo and A.V. Doubrovskii, 1981), and the patients were demonstrated at the session of the thoracal section of the Moscow Surgical Society. It was the first case where the pulmonological surgeon was made sure of a possibility to remove the metastases without chemotherapy (by the way, being of restricted efficacy in this type of cancer). The histology of the preparations had to be consulted twice, and the diagnosis remained unaltered. Patient Sh. was followed-up for 8.5 years, with no pathology observed. In 1984 she died of cardiac attack, with the post-mortem examination revealing no signs of cancer.

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Figure 1. Roentgenogram of patient Sh. prior to surgery. Adjacent to the right contour of the heart is an 8´13-cm large homogeneous shadow with clear-cut contours. More laterally, there are three round homogeneous foci with distinct edges, with a diameter of 1.5-2 cm (at the level of the anterior portions of ribs I, IV, and VII). In the left lung, there are two similar foci at the level of intercoastal spaces II and IV.

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Figure 2. Three weeks after the operation and prior to IET. In the lower lateral portion of the right lung there are massive pleural over lapping, with two round foci remaining in the left lung.

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Figure 3. One month after IET. In the place of the metastatic foci in the left lung, there is a considerably less in size shadow at the level of intercoastal space IV. 4.5 years after the operation and the IET, the round foci in the left lung are not detected. The pulmonary picture is normal.

Case Report #2

Patient Sh., husband of the previous woman. He was operated on the same day with his wife. The clinical-roentgenological diagnosis: rapidly growing tumour of the lower lobe of the right lung. The transthoracic puncture yielded the cells resembling malignant ones. The patient was subjected to resection of the lower and middle lobe of the right lung with enucleation of the lymph nodes in the root of the lung, and in the mediastinum. Histologically – squamous-cell carcinoma with elements of decomposition.

 

The immunological examination performed on November 25th, 1975 revealed high concentration of the blocking factors in the blood serum, on the same day the IET was carried out. Four months after, the blocking factor in blood was not detected. In 1976, the patient again developed coughing with sputum, presenting infiltrative shadow in the upper lobe of the right lung. The patient underwent antibacterial therapy and the repeated IET. Being a citizen of the Ukraine, he then was examined, with no pathology revealed, but after 1991, we received no data concerning him.

Case Report #3

Patient L., female, born in 1946. She was operated on November 19th, 1980 for breast cancer, following surgery she underwent several courses of chemotherapy (by the Couper technique), in spite of these attempts, in 1981 she developed metastases into the bone. The IET was begun on July 28th, 1981. Currently, she is apparently healthy, able-bodied, presenting no complaints.

Case Report #4

Patient L-va, female, born in 1938, was operated (bone resection) at the Kharkov Research Institute of Traumatology and Orthopaedics in 1975 for chondrosarcoma of the right femur. The IET was started in 1975, without any other treatment. Currently the patient is alive, presenting no complaints.

Case Report #5

Patient T., male, born in 1929. In 1978, he was operated on at the city of Kazan for right-sided pulmonary carcinoma. The physicians suspected metastases into the mediastinum and into the left lung. The patient refused the offered chemotherapy. The IET was started on December 21st, 1978. Presently, he works, having nothing to complain of.

Case Report #6

Patient P., male, born in 1936, was operated on twice for malignant melanoma in the area of the left femur (on December 23rd, 1989, and for the relapse thereof on April 29th, 1991), several courses of chemotherapy were performed in the city of Lvov. The IET was started on November 20th, 1991, after which no relapses were noted. Currently, he is apparently healthy, and able-bodied.

Case Report #7

Patient Sh., male, born in 1928. On January 2nd, 1992, he was operated on (by Professor V.B. Aleksandrov) for rectal cancer. The IET commenced in the same year following radiotherapy. Currently, the patient is able-bodied, presenting no complaints.

Case Report #8

Patient R., female. On September 4th, 1974 she underwent resection at the Central Institute of Traumatology and Orthopaedics (performed by Professor S.T. Zatsepin) according to the Pirogov technique for synovial sarcoma of the right foot. IET commenced from December 2nd, 1974. The patient developed neither relapses, nor metastases. She emigrated to Canada in 1991. Currently she is alive, presenting no complaints.

Case Report #9

Patient G., born in 1929. In 1986, he was operated on for breast cancer (male). The surgical intervention was followed by chemotherapy which the patient refused to continue. The IET was started on December 9th, 1986. The patient is apparently healthy to the present day.

Case Report #10

Patient B., female, born in 1954. Following mastectomy and chemotherapy for breast cancer, a solitary metastasis into the bones of the upper thoracic portion of the vertebral column was revealed in 1995. It was supposed to be removed surgically, but we decided to preliminarily perform the IET. Three months after, positive dynamics was observed, with no operation needed. Currently, roentgenological examination reveals no pathological alterations, with the patient presenting no complaints whatsoever.

It seems currently difficult to speak of permanent cure of the patients, even ten years after. Generally, in case of cancer, even if complete remission in patients is noted for 10 years, we can speak of recovery as such only conditionally. For the cause of the disease is not known, and is not removed completely. We followed up two patients subjected to the IET, in whom remission lasted 6 years (squamous-cell carcinoma of the lung) and 14 years (renal carcinoma, hypernephroma), after which the patients rapidly developed progressing complications (in the first case – a mediastinal tumour, and in the second case – a metastatic lesion to the liver). It bears evidence that the genetic prerequisites of carcinogenesis preserve for a long time, and the tumour can acquire resistance to any therapeutic modality.

It is also difficult to speak of statistics, since our task was to study the immune status of oncological patients, dynamics of the indices before and after treatment, working out of an optimal and safe therapeutic regimen. Therefore, the IET was carried out in a limited number of patients, the majority of whom visited us at late stages of the disease, after unsuccessful combined treatment. We abstained from carrying out such treatment in patients with malignant lesions to the blood system (and, consequently, the immunity system), and could not attain remission in total metastatic involvement (stage 4) and presence of metastases into the liver. Amongst the patients, those who survived after IET with no manifestations of the disease for 10 years and more (patients with breast cancer, carcinoma of the lung, womb, and other organs – stage IIA-III) amount to about 50 %. In none of the cases we noted any short- or long-term complications of the IET, which turned out inefficient, at the most.

The comparative ease and availability of the suggested method, especially taking into consideration the current economic condition of medicine, makes it possible to recommend implementation thereof in oncological practice, not refusing the commonly adopted methods of treatment. The combination with radiotherapy might promote protection of the haemopoietic function, however requiring to be specified. In cases, wherein the patients were subjected to chemotherapy, we for two months undertook nonspecific stimulation with various modulators of immunity, to be followed by the IET.

Placenta (from Greek plakount – ”a pie, flat cake”) is the most important organ of pregnancy, and a multi-modality functional cunning gadget providing protection and nourishment of the foetus. Being almost completely impermeable to the white cells of the mother’s blood, it serves as a filter for immune cells and a plurality of antibodies, passing through only those globulins which are indispensable for resistibility of the infant-to-be. In the mammals, the external layer of the trophoblast develops around the tiny embryo as early as on day 8-9 of its life. Soon, it is divided into two layers, with the external layer forming numerous villi which are implanted into the mucous membrane of the uterus, wherein there is an already prepared bed stuffed with immunosuppressor molecules, the mother’s part of the placenta – decidua.

The trophoblast is the so-called no-man’s land, bearing no proteins of tissular incompatibility, a unique in its kind tissue. The matured placenta is known to consist of lobes amounting to over 200 in number. On day 20 of gestation, the placenta occupies about the half of the womb. Each of the numerous villi bears the embryo’s blood vessels whose total area gradually reaches from 15 to 20 square metres. The nowhere-mixing blood flows of the mother and foetus are divided with a thin plate through which there takes place diffusion of oxygen, mineral and nutrient substances. At the same time, the trophoblast actively generates regulatory products, growth factors, and hormones, preparing the mother’s body to delivery and breast feeding. It is also the place of location of multiple cellular ”factories” producing the blocking factors, activators of suppressor-lymphocytes, remote tamers of immunity.

Extracts prepared from the tissues of the trophoblast do not contain the series-A-and-B HLA antigens, nor HLA-antibodies. At the same time, they contain chorionic gonadotropin at a concentration of 3-5 IU/ml, progesterone, (up to 3 mcg/g, IgA 15 – 20 mg/%, IgG (up to 500 mg/%, IgM is absent.

A more sophisticated technology of manufacturing the placental products consists in creation of hybridoma of cells of the trophoblast at the peak of their functional activity (following caesarean section), and myeloma cells. The purified preparations obtained with this biotechnological method should be thoroughly checked up, including also in interaction of the recipient’s lymphocytes with tumour proteins. Currently, such modification is under the patent examination.

Further Case Studies:

Patient: Inna, female, date of birth 6/26/69

Symptoms: 1998, liver pains, weakness, chronic fatigue since 1996.

Condition: Sonogram showed in 1996: shading on liver, well defined, 7×12 cm.

Second sonogram in 1977 showed growth to 8×13 cm . In 1998 biopsy proved

Treatment in 1998: liver cleansing, detoxification, 7  doses VG-1000.

Result: pain subsides, weakness reduced.

Treatment in 1999:  cleansing and detoxification ,  5 weeks VG-1000

at 2 doses per week.

Since 2001: Every month 3-5 doses.

Result: Woman’s condition has improved to a point that now she lives normally.

Patient: Steven, male, born 1949.

Symptoms : 1997: none, but PSA 9,8, free PSA 0,6, relation 6%.

Rectal touché and biopsy left and right prostate lobe :positive. Gleason:3+3.

Refuses surgery ( radical prostatectomy).

Treatment in 1997: detoxification, Hulda Clark and Gerson therapy: PSA < 6.

In 1998: PSA >12. Start 50 drip infusions Vit C, Taurine and Reduced Gluthation.

Takes food supplements : zinc, genistein, selenium and lycopene.

Regular physical and blood analyses proves no metastasis, PSA <8.

In 2001:  frequent doses Vg-1000.

In 2002: takes PC-Spes in high doses. PSA drops to immeasurable values.

In 2003: urologist can not detect any solid tissue in the prostate, bone and all others cans

Stay negative. Patient suffers from side effects like gynaemasty, deep vein thrombosis and weight gain, but reduce all treatment slowly in 2004 and lives normally.

Patient: Monique, female, born 1961.

Symptoms/diagnosis: In 1999: uterus carcinoma grade III, stadium III  plus metastasis.

Treatment :  surgery  removing uterus sarcoma, no supplementary  radiation.

Start Hulda Clark treatment, and takes 7 gram Vit C , selenium, lactobacillus complex, Bioplacental on a daily base.

In 2001 start Vg-1000 2 times a week during 3 months, slowly reduced to2 injections per year.  Her surprised gynecologist confirms in 2003 : No signs of metastasis or new tumors  we control patient on low frequency 1 time per year.

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