The Biological Immune Modifier VG 1000 was discovered by Professor Victor Govallo in the early 1960’s of the last century. See: VG 1000 in the Shop bar . The injectable pilot product had to be shipped in dry ice, and was complicated and expensive. In the 1980’s the extract could be lyophilized (freeze dried) and used parenteral ( by intramuscular ) injection as well, sublingual (under the tongue). About 6 years ago the third generation was introduced : VG 1000 suppositories for rectal or vaginal application. After extensive application research VG 1000 DUAL PATCHES for transdermal use are now available, as an elegant patient friendly, safe and active innovated product.

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Quantity

1 Zip Bag

S$ 598,00 SGD

Equal to:

THB 14,226.04

USD 438.26

EURO 372.74

GBP 333.36

Use the bank order form and get FREE Patches !!

Introduction :

A lot of progress has been done in the field of Transdermal Patches. Due to large advantages of the Transdermal Drug Delivery System, this system interests a lot of researchers. Many new researches are going on in the present day to incorporate newer drugs via this system. Various devices which help in increasing the rate of absorption and penetration of the drug are also being studied. However, in the present time due to certain disadvantages like large drug molecules cannot be delivered, large dose cannot be given, the rate of absorption of the drug is less, skin irritation, the use of the Transdermal Drug Delivery System has been limited. But, with the invention of the new devices and new drugs which can be incorporated via this system, it used is increasing rapidly in the present time. These days even “ buccal” patches : oral dissolvable films , are in clinical trial.

Transdermal drug delivery :

One such advance has been the development of transdermal patch delivery systems. Transdermal drug technology specialists are continuing to search for new methods that can effectively and painlessly deliver larger molecules in therapeutic quantities to overcome the difficulties associated with the oral route. Transdermal Drug Delivery System is the system in which the delivery of the active ingredients of the drug occurs by the means of skin. Skin, as our biggest organ, is an effective medium from which absorption of the drug takes place and enters the circulatory system. Various types of transdermal patches are used to incorporate the active ingredients into the circulatory system via skin. The patches have been proved safe and effective because of its large advantages of convenience in use over other controlled drug delivery systems. The active ingredients in Vg 1000 Dual Patches penetrates through the skin and reaches the systemic circulation.

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Transdermal drug delivery system has been in existence for a long time. In the past, the most commonly applied systems were topically applied creams and ointments for dermatological disorders. The occurrence of systemic side-effects with some of these formulations is indicative of absorption through the skin. A number of drugs have been applied to the skin for systemic treatment. In a broad sense, the term transdermal delivery system includes all topically administered drug formulations intended to deliver the active ingredient into the general circulation. Transdermal therapeutic systems have been designed to provide controlled continuous delivery of drugs via the skin to the systemic circulation. Moreover, it overcomes various side effects like painful delivery of the drugs and the first pass metabolism of the drug occurred by other means of drug delivery systems. So, this Transdermal Drug Delivery System has been a great field of interest in the recent time. Many drugs which can be injected directly into the blood stream via skin have been formulated. The main advantages of this system are that there is controlled release of the drug and the medication is painless.  The drug is mainly delivered to the skin with the help of a transdermal patch which adheres to the skin. A Transdermal Patch has several components like liners, adherents, drug reservoirs, drug release membrane etc. which play a vital role in the release of the drug via skin. Various types of patches along with various methods of applications have been invented  to deliver the drug from the transdermal patch. Because of its great advantages, it has become one of the highly research fields among the various drug delivery system.

Types of transdermal patches :

Single-layer Drug-in-Adhesive 
The adhesive layer of this system also contains the drug. In this type of patch the adhesive layer not only serves to adhere the various layers together, along with the entire system to the skin, but is also responsible for the releasing of the drug. The adhesive layer is surrounded by a temporary liner and a backing.

Multi-layer Drug-in-Adhesive 
The multi-layer drug-in adhesive patch is similar to the single-layer system in that both adhesive layers are also responsible for the releasing of the drug. The multi-layer system is different however that it adds another layer of drug-in-adhesive, usually separated by a membrane (but not in all cases). This patch also has a temporary liner-layer and a permanent backing.

Reservoir 
Unlike the Single-layer and Multi-layer Drug-in-adhesive systems the reservoir transdermal system has a separate drug layer. The drug layer is a liquid compartment containing a drug solution or suspension separated by the adhesive layer. This patch is also protected by the backing layer. In this type of system the rate of release is zero order.

Matrix
The Matrix system has a drug layer of a semisolid matrix containing a drug solution or suspension. The adhesive layer in this patch surrounds the drug layer partially overlaying it. The new Hydrogel Patches are a good example.

Vapour Patch 
In this type of patch the adhesive layer not only serves to adhere the various layers together but also to release vapour. The vapour patches are new on the market and they release essential oils for up to 6 hours. The vapours patches release essential oils and are used in cases of decongestion mainly. Other vapour patches on the market are controller vapour patches that improve the quality of sleep. Vapour patches that reduce the quantity of cigarettes that one smokes in a month are also available on the market. Nicotine: to quit tobacco smoking , Fentanyl: analgesic for severe pain, Estrogen: menopause and osteoporosis , Nitroglycerin: angina , Lidocaine: peripheral pain of shingles (herpes zoster). Recent developments expanded their use to the delivery of hormonal contraceptives, antidepressants and even pain killers and stimulants for Attention Deficit Hyperactivity Disorder/ADHD.

The Vg 1000 Dual Patch is manufactured under low temperature conditions to avoid any lost of the original biologically active protein compound Biological Immune Modifier VG 1000! Usually this type of patches are made from waste paper pulp, when this low quality packing touches water, or body liquid like sweat , it will break up at once.  The Vg 1000 Dual Patch is made out of non woven, environment-friendly fabrics. It is flat and soft and there is not any gofer on it. It is a non occlusive patch.  This patch has a so called biphasic approach : the outer covering contains the Vg 1000 extract , due to its molecular weight < 1,000 nanometers: the nanoparticles will be fast absorb within 20 minutes.  The reservoir contains natural detoxification compounds > 10 micron with a slow release effect of approximately 12-15 hours.  Main biological ingredients are micronized herbals like fennel, peppermint, dandelion, liquorices, black haw and others.  All these valuable biological components do not reach the gastro-intestinal tract. So it cannot be inactivated by other organs, or undergoes first pass metabolism in the liver.  It improves the patient’s compliance, which easily can control whether or not been taken, or stop immediately the administration by removing the patch. 

Method of administration :

Vg 1000 Dual Patches are used by sticking it to non-irritated, non-irradiated , non hairy body parts, such as  flat surface of the torso, upper leg, back, abdomen, upper arm and  soles of the feet just before bedtime. Apply to upper back in people with cognitive impairment to decrease the potential of the patient removing the patch. If the site requires cleansing prior to application of the patch, this should be done with water. Soaps, oils lotions, alcohol or other agent that might irritate the skin or alter its characteristics should not be used. The skin should be completely dry before application of the patch.  When taking a shower the patch should be removed, as it is not waterproof.

The patch should be attached as soon as the ZIP bag has been opened. Following removal of the protective layer, the transdermal patch should be pressed firmly in place with the palm of the hand for approximately 30 seconds, thus  making sure that the contact is complete, especially around the edges. Keep the ZIP bag closed. After a couple of  hours, results are immediately seen and felt. The Patches turn from a dry white pad to a damp, brownish-gray pad on which you can clearly see the pain-causing toxins extracted from your body. The darker a pad becomes, the larger the amount of toxins adsorbed. It then has the smell of “tar”. As with any detoxification treatment: as soon as toxins are extracted from the body, one experiences improved blood circulation, easing of muscle and joint pains, and a more relaxed and restful sleep.
After removal of the patch, you will notice sticky dark residues on the skin, these can be cleaned off with soap and plenty of  lukewarm water. In no case should alcohol or other solvents be used for cleansing as these could penetrate the skin due to the effect of the patch. The transdermal patch should not be divided, as it will lose its biological activity.

Dosage :

The usual dosage is one patch in the night, during 5 weekdays. However, for a faster result another patch can be used in the morning to use in the daytime. Or as prescribed by your physician. How lighter the patch is after use, indicates success of treatment.

Indication :

The Vg 1000 Dual Patches are used in oncology and (auto) immune diseases.

Contra indications :

Vg 1000 Dual Patches cannot be used during MRI or other scans!!!
The U.S. Food and Drug Administration (FDA) issued a Public Health Advisory regarding certain adhesive patches that deliver medication through the skin. Some of the medicated patches have been found to be a risk to patient safety. The patches, if worn while undergoing magnetic resonance imaging scans or MRIs, can cause skin burns. Some patches contain metal in the layer of the patch that is not in contact with the skin (the backing). While not attracted to the magnetic field of the MRI, the metal can conduct electricity, generating heat which can cause burns. Users of the patches reported receiving skin burns at their patch site when wearing the patch during an MRI scan.
The risk of using a metallic patch during an MRI has been well-established, but the FDA recently discovered that not all manufacturers include a safety warning with their patches.

Side effects :

Due to decomposing and degradation of malignant cells and strong detoxification, together with the intended removal of body waste, important minerals like magnesium levels will decrease. This may cause leg cramps ( rare) during the first days/nights of treatment and will disappear. With application of each patch the intake of 300 milligram magnesium or a mineral supplement is advisable. Other minor side effects are redness or some heat on the application area, both are temporary and well tolerated.

Safe disposal or used patches :

Keep used patches out of the reach of children and pets, as the patches contain   significant quantities of body toxins! Used patches should be folded with the adhesive surfaces inwards, and due to safety and environmental reasons, discarded safely.

Storage :

Vg 1000 Dual Patches must be stored on a dry place at room temperature, with the ZIP back firmly closed. Do not freeze. Keep out of the reach of children and pets.

Expiration date : The expiration date is indicated on the Vg 1000 Dual Patches ZIP bag. If respecting the storage conditions, the biologically active ingredients in the unopened ZIP bag usually has a life time of about 4 years. The ingredients of patches in a re-opened ZIP bag remain biologically active for 6 months.

Presentations :

SEALED ZIP bag contains 5 Vg 1000 Dual Patches sufficient for a 5 days weekly treatment. For more details see ORDERFORM in the Navigator left side of the Home page. www.placenta-anticancer.info

Literature :

  1. Van Ewijk, William H. “ Placenta or the Lost Organ”, ISBN # 90-803874-1-X Here Available
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  3. Bayarski, Yury; Transdermal Drug Delivery, Transdermal Patches   
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  7. Arcangelo , Virginia P., Peterson, Andrew M.; Pharmacotherapeutics for Advanced Practice, Published by Lippincott Williams & Wilkins, 2005 Pg 74
  8. Kumar, Ritesh and Philip, Anil;  Modified Transdermal Technologies: Breaking the Barriers of Drug Permeation via the Skin; Tropical Journal of Pharmaceutical Research, March 2007; 6 (1): 633-644
  9. Jain N, Talegonkar S, Jain N K. New ways to enter the blood stream: Emerging strategies in transdermal drug delivery. The Pharma Review 2004; Oct.: 41- 59.
  10. Williams, Adrian; Transdermal and Topical Drug Delivery Published by Pharmaceutical Press, 2003; Pg: 14-18
  11. Elling, Bob, Elling, Kirsten M. Rothenberg, Mikel A.; Why-Driven EMS Enrichment Published by Thomson Delmar Learning, 2001 Pg 103
  12. Medscape Today journal 
  13. The Indian Anaesthetists’ Forum – On-Line Journal 
  14. Electroporation From Wikipedia, the free encyclopedia available
  15.  Neumann E, Schaefer-Ridder M, Wang Y, Hofschneider PH (1982). “Gene transfer into mouse lyoma cells by electroporation in high electric fields”. EMBO J. 1 (7): 841–5. PMID 6329708.
  16. Sugar IP, Neumann E (1984). “Stochastic model for electric field-induced membrane pores. Electroporation”. Biophys . Chem. 19 (3): 211–25. doi : 10.1016/0301-4622(84)87003-9. PMID 6722274
  17. ^ Sarah Yang ( 2007 – 02-12 ). ” New medical technique punches holes in cells, could treat tumors”. Retrieved on 2007 – 12-13 .
  18. Sonophoresis From Wikipedia, the free encyclopedia.
  19. Transdermal patch From Wikipedia, the free encyclopedia.
  20. Paranjape, Makarand; Biomedical Optics & Medical Imaging, Pain-free diabetic monitoring using transdermal patches.